Sheue-Yann Cheng Selected Research

Thyroid Hormone Receptors beta (TR beta)

7/2008	Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor.
12/2007	Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer.
10/2005	AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma.
9/2005	Chromosomal aberrations in cell lines derived from thyroid tumors spontaneously developed in TRbetaPV/PV mice.
9/2003	Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to thyroid hormone.
9/2003	Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis.
11/2002	Mice with a mutation in the thyroid hormone receptor beta gene spontaneously develop thyroid carcinoma: a mouse model of thyroid carcinogenesis.
3/2002	Functionally impaired TR mutants are present in thyroid papillary cancer.

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Sheue-Yann Cheng Research Topics

Disease

46	Neoplasms (Cancer) 01/2022 - 02/2002
27	Thyroid Neoplasms (Thyroid Cancer) 11/2021 - 03/2002
17	Carcinogenesis 06/2021 - 03/2002
10	Neoplasm Metastasis (Metastasis) 10/2020 - 02/2002
10	follicular Thyroid cancer 10/2020 - 10/2005
6	Follicular Adenocarcinoma 01/2014 - 09/2005
5	Breast Neoplasms (Breast Cancer) 01/2020 - 02/2002
4	Hypothyroidism 01/2021 - 03/2005
4	Obesity 10/2018 - 06/2016
4	Hyperplasia 01/2017 - 11/2002
4	Pituitary Neoplasms (Pituitary Adenoma) 04/2010 - 09/2003
3	Anaplastic Thyroid Carcinoma 06/2021 - 01/2019
3	Inflammation (Inflammations) 01/2020 - 06/2017
3	Anaplasia 10/2018 - 09/2003
2	Papillary Thyroid Cancer 06/2021 - 03/2002
2	Hematologic Neoplasms (Hematological Malignancy) 01/2019 - 01/2016
1	Muscle Weakness 01/2021
1	Muscular Diseases (Myopathy) 01/2021
1	Anemia 01/2021
1	Tuberculosis (Tuberculoses) 01/2021
1	Hyperthyroidism 01/2020
1	Developmental Bone Diseases (Bone Dysplasia) 01/2019
1	Hyperglycemia 01/2018
1	Hyperlipidemias (Hyperlipidemia) 01/2018
1	Hyperinsulinism (Hyperinsulinemia) 01/2018
1	Sarcopenia 10/2017
1	Melanoma (Melanoma, Malignant) 06/2017
1	Ischemic Stroke 02/2017
1	Vascular Remodeling 01/2017
1	Hypertrophy 01/2017

Drug/Important Bio-Agent (IBA)

18	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 01/2021 - 03/2002
16	Proteins (Proteins, Gene)FDA Link 06/2021 - 02/2002
15	Thyroid HormonesIBA 01/2021 - 09/2003
8	Messenger RNA (mRNA)IBA 06/2021 - 03/2002
8	Thyroid Hormone Receptors beta (TR beta)IBA 07/2008 - 03/2002
7	RacivirIBA 10/2020 - 04/2010
6	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2021 - 11/2002
5	Protein Isoforms (Isoforms)IBA 01/2021 - 10/2005
5	IntegrinsIBA 01/2019 - 04/2010
4	CytokinesIBA 12/2020 - 06/2017
4	Cyclin D1IBA 01/2017 - 09/2003
3	Metformin (Glucophage)FDA LinkGeneric 10/2018 - 06/2016
3	Complementary DNA (cDNA)IBA 01/2014 - 01/2011
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 07/2008 - 10/2005
2	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2021 - 01/2020
2	Small Interfering RNA (siRNA)IBA 01/2021 - 07/2009
2	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2021 - 01/2021
2	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 10/2020 - 09/2006
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019 - 10/2018
2	CyclinsIBA 01/2017 - 01/2017
2	Retinoblastoma ProteinIBA 01/2017 - 01/2012
2	Co-Repressor ProteinsIBA 05/2013 - 01/2013
2	Estrogens (Estrogen)FDA Link 01/2013 - 02/2002
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2013 - 01/2005
2	LipidsIBA 06/2011 - 11/2005
2	Biological ProductsIBA 11/2010 - 03/2010
2	TOR Serine-Threonine KinasesIBA 07/2010 - 12/2007
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 03/2010 - 01/2004
2	PPAR gammaIBA 11/2005 - 09/2003
1	crenigacestatIBA 01/2022
1	Aldehyde DehydrogenaseIBA 01/2022
1	CateninsIBA 01/2022
1	Death-Associated Protein KinasesIBA 11/2021
1	Serine (L-Serine)FDA Link 06/2021
1	CarbonIBA 06/2021
1	ChromatinIBA 01/2020
1	Hormones (Hormone)IBA 01/2020
1	Phenobarbital (Luminal)FDA Link 01/2020
1	Steroid Receptors (Steroid Receptor)IBA 01/2020
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	OsteopontinIBA 01/2019
1	PLX51107IBA 01/2019
1	Conditioned Culture MediaIBA 01/2019
1	mirdametinibIBA 01/2019
1	Histones (Histone)IBA 10/2018
1	Hypoglycemic Agents (Hypoglycemics)IBA 10/2018
1	Caspase 3 (Caspase-3)IBA 10/2018
1	SurvivinIBA 10/2018
1	Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)IBA 01/2018
1	AdipokinesIBA 01/2018
1	PhosphatidylserinesIBA 06/2017
1	InterferonsIBA 06/2017
1	Purinergic P2Y1 ReceptorsIBA 02/2017
1	Fatty Acids (Saturated Fatty Acids)IBA 02/2017
1	Adenosine Triphosphate (ATP)IBA 02/2017
1	Tyrosine (L-Tyrosine)FDA Link 01/2017
1	LeptinIBA 01/2017
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017
1	NSC 74859IBA 01/2017
1	Fibronectins (Fibronectin)IBA 06/2016
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2016
1	Matrix Metalloproteinases (MMPs)IBA 01/2016
1	Vorinostat FDA Link 01/2016
1	DNA (Deoxyribonucleic Acid)IBA 01/2016
1	ezrinIBA 01/2016
1	Testosterone (Sustanon)FDA Link 04/2015

Therapy/Procedure

6	Therapeutics 01/2022 - 07/2010
2	Immunotherapy 06/2017 - 04/2015
1	Castration 04/2015